The Association of Creactive Protein Levels in Second Trimester of Pregnancy with Preeclampsia

Abstract

Objective: To determine C-reactive protein in second trimester of pregnancy women who preeclamptic and non-preeclamptic women, and to determine the relationship between the level of C-Reactive protein of trimester two pregnancy and preeclampsia occurrence. Methods: This was a prospective study conducted at the policlinics of network of academic hospitals of the Department of Obstetrics and Gynecology of Faculty of Medicine, Universitas Hasanuddin and policlinic of child and mother, and some Public Health Centers in Makassar city from September 2015 - April 2016. The C-reactive protein 115 level of pregnant women in pregnancy age of 24-28 weeks was checked, whether the subjects underwent preeclampsia until the childbirth process. Statistics analysis used Fisher’s exact test and Mann Whitney test. Results: The result indicate that 9 subjects (7.8%) developed preeclampsia and 106 subjects did not become preeclampsia. The level of C-Reactive protein increased in preeclampsia group compared to non preeclampsia group i.e 5.05  1.153 : 3.36  0.265, but statistically the result is not significant (value p>0.05). Conclusion: The average score of C-Reactive protein of preeclampsia group is 33.5% higher than non-preeclampsia group, even though these results cannot be used as the score to predict the preeclampsia occurrence. Keywords: C-reactive protein, preeclampsia, second trimester pregnancy