Biological iron-sulfur storage in a thioferrate-protein nanoparticle

Brian J. Vaccaro; Sonya M. Clarkson; James F. Holden; Dong-Woo Lee; Chang-Hao Wu; Farris L. Poole II; Julien J. H. Cotelesage; Mark J. Hackett; Sahel Mohebbi; Jingchuan Sun; Huilin Li; Michael K. Johnson; Graham N. George; Michael W. W. Adams

doi:10.1038/ncomms16110

Nature Communications (Jul 2017)

Biological iron-sulfur storage in a thioferrate-protein nanoparticle

Brian J. Vaccaro,
Sonya M. Clarkson,
James F. Holden,
Dong-Woo Lee,
Chang-Hao Wu,
Farris L. Poole II,
Julien J. H. Cotelesage,
Mark J. Hackett,
Sahel Mohebbi,
Jingchuan Sun,
Huilin Li,
Michael K. Johnson,
Graham N. George,
Michael W. W. Adams

Affiliations

Brian J. Vaccaro: Department of Chemistry, University of Georgia
Sonya M. Clarkson: Department of Biochemistry and Molecular Biology, University of Georgia
James F. Holden: Department of Biochemistry and Molecular Biology, University of Georgia
Dong-Woo Lee: Department of Biochemistry and Molecular Biology, University of Georgia
Chang-Hao Wu: Department of Biochemistry and Molecular Biology, University of Georgia
Farris L. Poole II: Department of Biochemistry and Molecular Biology, University of Georgia
Julien J. H. Cotelesage: Department of Geological Sciences and Chemistry, University of Saskatchewan
Mark J. Hackett: Department of Geological Sciences and Chemistry, University of Saskatchewan
Sahel Mohebbi: Department of Chemistry, University of Georgia
Jingchuan Sun: Cryo-EM Structural Biology Laboratory, Center for Epigenetics, Van Andel Research Institute
Huilin Li: Cryo-EM Structural Biology Laboratory, Center for Epigenetics, Van Andel Research Institute
Michael K. Johnson: Department of Chemistry, University of Georgia
Graham N. George: Department of Geological Sciences and Chemistry, University of Saskatchewan
Michael W. W. Adams: Department of Biochemistry and Molecular Biology, University of Georgia

DOI: https://doi.org/10.1038/ncomms16110
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

Read online

The biosynthesis of iron-sulfur clusters in anaerobic organisms has not been extensively investigated. Here, the authors identify and characterize a multi-subunit protein that stores iron and sulfur in thioferrate for the assembly of the clusters inPyrococcus furiosus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal