Nature Communications (Oct 2019)
Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7
- Kyoko Hanawa-Suetsugu,
- Yuzuru Itoh,
- Maisarah Ab Fatah,
- Tamako Nishimura,
- Kazuhiro Takemura,
- Kohei Takeshita,
- Satoru Kubota,
- Naoyuki Miyazaki,
- Wan Nurul Izzati Wan Mohamad Noor,
- Takehiko Inaba,
- Nhung Thi Hong Nguyen,
- Sayaka Hamada-Nakahara,
- Kayoko Oono-Yakura,
- Masashi Tachikawa,
- Kenji Iwasaki,
- Daisuke Kohda,
- Masaki Yamamoto,
- Akio Kitao,
- Atsushi Shimada,
- Shiro Suetsugu
Affiliations
- Kyoko Hanawa-Suetsugu
- Nara Institute of Science and Technology
- Yuzuru Itoh
- University of Tokyo
- Maisarah Ab Fatah
- Nara Institute of Science and Technology
- Tamako Nishimura
- Nara Institute of Science and Technology
- Kazuhiro Takemura
- School of Life Science and Technology, Tokyo Institute of Technology
- Kohei Takeshita
- RIKEN SPring-8 Center
- Satoru Kubota
- Nara Institute of Science and Technology
- Naoyuki Miyazaki
- Institute for Protein Research, Osaka University
- Wan Nurul Izzati Wan Mohamad Noor
- Nara Institute of Science and Technology
- Takehiko Inaba
- Nara Institute of Science and Technology
- Nhung Thi Hong Nguyen
- Nara Institute of Science and Technology
- Sayaka Hamada-Nakahara
- University of Tokyo
- Kayoko Oono-Yakura
- Nara Institute of Science and Technology
- Masashi Tachikawa
- Theoretical Biology Laboratory, RIKEN
- Kenji Iwasaki
- Institute for Protein Research, Osaka University
- Daisuke Kohda
- RIKEN SPring-8 Center
- Masaki Yamamoto
- RIKEN SPring-8 Center
- Akio Kitao
- School of Life Science and Technology, Tokyo Institute of Technology
- Atsushi Shimada
- RIKEN SPring-8 Center
- Shiro Suetsugu
- Nara Institute of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-019-12738-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The Bin/Amphiphysin/Rvs167 (BAR) domain superfamily, which includes FCH-BAR (F-BAR) domain proteins are membrane-sculpting proteins. Here the authors combine a range of techniques and show that the F-BAR domain of growth-arrest specific protein 7 (GAS7) forms two-dimensional sheets on flat membranes and that these oligomeric assemblies of GAS7 are required for the formation of phagocytic cups in macrophages.
