Seroprevalence of antibodies against diphtheria, tetanus, and pertussis across various age groups during the post-COVID-19 pandemic period in Chonburi Province, Thailand
Nasamon Wanlapakorn,
Nungruthai Suntronwong,
Sitthichai Kanokudom,
Suvichada Assawakosri,
Preeyaporn Vichaiwattana,
Sirapa Klinfueng,
Lakana Wongsrisang,
Thanunrat Thongmee,
Ratchadawan Aeemjinda,
Nongkanok Khanarat,
Donchida Srimuan,
Thaksaporn Thatsanathorn,
Ritthideach Yorsaeng,
Apirat Katanyutanon,
Wichai Thanasopon,
Wichan Bhunyakitikorn,
Chaninan Sonthichai,
Piyada Angsuwatcharakorn,
Withak Withaksabut,
Jira Chansaenroj,
Natthinee Sudhinaraset,
Yong Poovorawan
Affiliations
Nasamon Wanlapakorn
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Nungruthai Suntronwong
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Sitthichai Kanokudom
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand; Center of Excellence in Osteroarthritis and Musculoskeleton, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, 10330, Thailand
Suvichada Assawakosri
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand; Center of Excellence in Osteroarthritis and Musculoskeleton, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, 10330, Thailand
Preeyaporn Vichaiwattana
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Sirapa Klinfueng
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Lakana Wongsrisang
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Thanunrat Thongmee
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Ratchadawan Aeemjinda
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Nongkanok Khanarat
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Donchida Srimuan
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Thaksaporn Thatsanathorn
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Ritthideach Yorsaeng
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Apirat Katanyutanon
Chonburi Provincial Public Health Office, Bansuan, Mueang Chonburi, Chonburi, 20000, Thailand
Wichai Thanasopon
Chonburi Provincial Public Health Office, Bansuan, Mueang Chonburi, Chonburi, 20000, Thailand
Wichan Bhunyakitikorn
Division of Communicable Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
Chaninan Sonthichai
Vaccine Protection, Division of Communicable Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
Piyada Angsuwatcharakorn
Vaccine Protection, Division of Communicable Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
Withak Withaksabut
Chonburi Provincial Public Health Office, Bansuan, Mueang Chonburi, Chonburi, 20000, Thailand
Jira Chansaenroj
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Natthinee Sudhinaraset
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
Yong Poovorawan
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand; FRS(T), the Royal Society of Thailand, Sanam Sueapa, Dusit, Bangkok, 10300, Thailand; Corresponding author. Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Background: Limited data exists regarding population immunity against diphtheria, tetanus, and pertussis in Thailand during the post-COVID-19 pandemic period. This study aimed to evaluate the age-specific seroprevalence of anti-diphtheria toxoid (anti-DT) IgG, anti-tetanus toxoid (anti-TT) IgG, and anti-pertussis toxin (anti-PT) IgG in individuals across diverse age groups in Chonburi province, Thailand following the COVID-19 pandemic. Methods: Between October 2022 and January 2023, a total of 657 participants from Chonburi Province, Thailand, were included in this study. The participants were categorized into 9 age groups: 70 years. Analysis of anti-DT, anti-TT, and anti-PT IgG levels was conducted using commercial ELISA kits (EUROIMMUN, Lübeck, Germany). Results: Overall, 65.4 % of the population had seroprotection against diphtheria (antibody level ≥0.1 IU/mL), while 95.1 % had seroprotection against tetanus (antibody level ≥0.1 IU/mL). The 31–40 years age group exhibited the lowest seroprotection for diphtheria (48.9 %), and the >70 years age group had the lowest seroprotection for tetanus (73.3 %). The <5 years age group showed the highest seropositive rate and highest geometric mean titers for anti-PT IgG. On the contrary, the majority of individuals over 11 years of age displayed anti-PT IgG levels below 40 IU/mL. Conclusions: To prevent diphtheria and pertussis outbreaks in Chonburi province, implementing catch-up vaccination is necessary. Targeted interventions should be deployed to enhance vaccination coverage among the susceptible population.
