Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites

P. Dean; K. M. Sendra; T. A. Williams; A. K. Watson; P. Major; S. Nakjang; E. Kozhevnikova; A. V. Goldberg; E. R. S. Kunji; R. P. Hirt; T. M. Embley

doi:10.1038/s41467-018-03923-4

Nature Communications (Apr 2018)

Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites

P. Dean,
K. M. Sendra,
T. A. Williams,
A. K. Watson,
P. Major,
S. Nakjang,
E. Kozhevnikova,
A. V. Goldberg,
E. R. S. Kunji,
R. P. Hirt,
T. M. Embley

Affiliations

P. Dean: Institute for Cell & Molecular Biosciences, Medical School, University of Newcastle upon Tyne
K. M. Sendra: Institute for Cell & Molecular Biosciences, Medical School, University of Newcastle upon Tyne
T. A. Williams: Institute for Cell & Molecular Biosciences, Medical School, University of Newcastle upon Tyne
A. K. Watson: Institute for Cell & Molecular Biosciences, Medical School, University of Newcastle upon Tyne
P. Major: Institute for Cell & Molecular Biosciences, Medical School, University of Newcastle upon Tyne
S. Nakjang: Institute for Cell & Molecular Biosciences, Medical School, University of Newcastle upon Tyne
E. Kozhevnikova: Institute for Cell & Molecular Biosciences, Medical School, University of Newcastle upon Tyne
A. V. Goldberg: Institute for Cell & Molecular Biosciences, Medical School, University of Newcastle upon Tyne
E. R. S. Kunji: Medical Research Council Building, Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus
R. P. Hirt: Institute for Cell & Molecular Biosciences, Medical School, University of Newcastle upon Tyne
T. M. Embley: Institute for Cell & Molecular Biosciences, Medical School, University of Newcastle upon Tyne

DOI: https://doi.org/10.1038/s41467-018-03923-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Microsporidia are obligate intracellular parasites that infect both humans and animals. Here, Dean et al. perform ancient gene reconstruction and functional assays to investigate the evolution and functional diversification of nucleotide transporters which are key to the parasite's intracellular lifestyle.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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