Bioactive Materials (Jul 2022)
Adhesive anastomosis for organ transplantation
- Kang Liu,
- Hang Yang,
- Gaobo Huang,
- Aihua Shi,
- Qiang Lu,
- Shanpei Wang,
- Wei Qiao,
- Haohua Wang,
- Mengyun Ke,
- Hongfan Ding,
- Tao Li,
- Yanchao Zhang,
- Jiawei Yu,
- Bingyi Ren,
- Rongfeng Wang,
- Kailing Wang,
- Hui Feng,
- Zhigang Suo,
- Jingda Tang,
- Yi Lv
Affiliations
- Kang Liu
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Hang Yang
- State Key Lab for Strength and Vibration of Mechanical Structures, International Center for Applied Mechanics, Department of Engineering Mechanics, Xi'an Jiaotong University, Xi'an, 710049, China; John A. Paulson School of Engineering and Applied Science, Kavli Institute for Bionano Science and Technology, Harvard University, Cambridge, MA, 02138, USA
- Gaobo Huang
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Aihua Shi
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Qiang Lu
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Shanpei Wang
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Wei Qiao
- Hepatobiliary Surgery Department, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi Province, China
- Haohua Wang
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Mengyun Ke
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Hongfan Ding
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Tao Li
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Yanchao Zhang
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Jiawei Yu
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Bingyi Ren
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Rongfeng Wang
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Kailing Wang
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Hui Feng
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China
- Zhigang Suo
- John A. Paulson School of Engineering and Applied Science, Kavli Institute for Bionano Science and Technology, Harvard University, Cambridge, MA, 02138, USA; Corresponding author.
- Jingda Tang
- State Key Lab for Strength and Vibration of Mechanical Structures, International Center for Applied Mechanics, Department of Engineering Mechanics, Xi'an Jiaotong University, Xi'an, 710049, China; Corresponding author.
- Yi Lv
- National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China; Corresponding author.
- Journal volume & issue
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Vol. 13
pp. 260 – 268
Abstract
The recent development of tough tissue adhesives has stimulated intense interests among material scientists and medical doctors. However, these adhesives have seldom been tested in clinically demanding surgeries. Here we demonstrate adhesive anastomosis in organ transplantation. Anastomosis is commonly conducted by dense sutures and takes a long time, during which all the vessels are occluded. Prolonged occlusion may damage organs and even cause death. We formulate a tough, biocompatible, bioabsorbable adhesive that can sustain tissue tension and pressurized flow. We expose the endothelial surface of vessels onto a gasket, press two endothelial surfaces to the adhesive using a pair of magnetic rings, and reopen the bloodstream immediately. The time for adhesive anastomosis is shortened compared to the time for sutured anastomosis. We have achieved adhesive anastomosis of a great vein in transplanting the liver of a pig. After the surgery, the adhesive is absorbed, the vein heals, and the pig lives for over one month.
