Reference ranges of fetal heart function using a Modified Myocardial Performance Index: a prospective multicentre, cross-sectional study
Xiaoming Zhang,
Wei Zhao,
Yuqing Zhou,
Hong Lu,
Jingjing Wang,
Wei Guo,
Wenjun Zhang,
Sheng Zhao,
Na Zhang,
Lan Yu,
Lijuan Sun,
Yuxin Jiang,
QingQing Wu,
Zhen Li,
Xiaoting Su,
Xinlin Chen,
Jianmei Niu,
Congxin Sun,
Jijing Han,
Lina Zhang,
Zhenna Wang,
Peiwen Chen,
Tiantian Chen,
Hua Hong,
Lulu Zhou,
Baoying Ye,
Jiawei Tian
Affiliations
Xiaoming Zhang
University of Chinese Academy of Sciences, Beijing, China
Wei Zhao
3 Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Yuqing Zhou
First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China
Hong Lu
Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jingjing Wang
Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, Tongji University, Shanghai, China
Wei Guo
1 Department of Stem Cell & Regenerative Medicine, Daping Hospital, Army Military Medical University,Chongqing, Chongqing, China
Wenjun Zhang
Department of Medical Ultrasound, Taihe Hospital, Hubei University of Medicine, Hubei, China
Sheng Zhao
Department of Ultrasound, Maternal and Child Health Hospital of Hubei Province, Hubei, China
Na Zhang
Department of Ultrasound, Beijing Obstetrics and Gynecology hospital, Capital Medical University, Beijing, China
Lan Yu
National Clinical Research Center for Child Health, Children`s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Lijuan Sun
Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China
Yuxin Jiang
Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
QingQing Wu
Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China
Zhen Li
Department of Ultrasound, Beijing Obstetrics and Gynecology hospital, Capital Medical University, Beijing, China
Xiaoting Su
3 National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Beijing, China
Xinlin Chen
Department of Ultrasound, Maternal and Child Health Hospital of Hubei Province, Hubei, China
Jianmei Niu
Department of Ultrasound, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Congxin Sun
Department of Ultrasound, Shijiazhuang Obstetrics and Gynecology Hospital, Hebei, China
Jijing Han
Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China
Lina Zhang
Department of Ultrasound, Beijing Obstetrics and Gynecology hospital, Capital Medical University, Beijing, China
Zhenna Wang
Department of Ultrasound, Qingdao Women and Children’s Hospital, Shandong, China
Peiwen Chen
Department of Ultrasound, Maternal and Child Health Hospital of Hubei Province, Hubei, China
Tiantian Chen
Department of Ultrasound, Shanghai Changning Maternity & Infant Health Hospital, Shanghai, China
Hua Hong
Department of Ultrasound, Inner Mongolia people’s hospital, Inner Mongolia, China
Lulu Zhou
Department of Ultrasound, Women’s Hospital School of Medicine Zhejiang University, Zhejiang, China
Baoying Ye
Department of Ultrasound, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Jiawei Tian
Department of Ultrasound, the Second Affiliated Hospital of Harbin Medicine University, Heilongjiang, China
Objectives The primary aim of this study was to establish the normal reference ranges of the fetal left ventricular (LV) Modified Myocardial Performance Index (Mod-MPI). A secondary aim was to evaluate the agreement between manual and automatic measurements for fetal Mod-MPI.Design A prospective, multicentre, cross-sectional study.Participants Normal singleton pregnancies.Methods The LV functions of normal singleton pregnancies were assessed in nine centres covering eight provinces in China using unified ultrasound protocols and settings and standardised measurements by pulsed Doppler at 20–24, 28–32 and 34–38 weeks of gestation. The isovolumetric relaxation time (IRT), isovolumetric contraction time, ejection time (ET) and Mod-MPI were measured both automatically and manually.Results This cross-sectional study included 2081 fetuses, and there was a linear correlation between gestational age (GA) and Mod-MPI (0.416+0.001×GA (weeks), p<0.001, r2=0.013), IRT (36.201+0.162× GA (weeks), p<0.001, r2=0.021) and ET (171.418–0.078*GA (weeks), p<0.001, r2=0.002). This finding was verified using longitudinal data in a subgroup of 610 women. The agreement between the manual and automated measurements for Mod-MPI was good.Conclusions We constructed normal reference values of fetal LV Mod-MPI. Automatic measurement can be considered for ease of measurement in view of the good agreement between the automatic and manual values.
