PLoS ONE (Jan 2013)

The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts.

  • Matthew R Gingo,
  • G K Balasubramani,
  • Lawrence Kingsley,
  • Charles R Rinaldo,
  • Christine B Alden,
  • Roger Detels,
  • Ruth M Greenblatt,
  • Nancy A Hessol,
  • Susan Holman,
  • Laurence Huang,
  • Eric C Kleerup,
  • John Phair,
  • Sarah H Sutton,
  • Eric C Seaberg,
  • Joseph B Margolick,
  • Stephen R Wisniewski,
  • Alison Morris

DOI
https://doi.org/10.1371/journal.pone.0058812
Journal volume & issue
Vol. 8, no. 3
p. e58812

Abstract

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ObjectiveTo review the incidence of respiratory conditions and their effect on mortality in HIV-infected and uninfected individuals prior to and during the era of highly active antiretroviral therapy (HAART).DesignTwo large observational cohorts of HIV-infected and HIV-uninfected men (Multicenter AIDS Cohort Study [MACS]) and women (Women's Interagency HIV Study [WIHS]), followed since 1984 and 1994, respectively.MethodsAdjusted odds or hazards ratios for incident respiratory infections or non-infectious respiratory diagnoses, respectively, in HIV-infected compared to HIV-uninfected individuals in both the pre-HAART (MACS only) and HAART eras; and adjusted Cox proportional hazard ratios for mortality in HIV-infected persons with lung disease during the HAART era.ResultsCompared to HIV-uninfected participants, HIV-infected individuals had more incident respiratory infections both pre-HAART (MACS, odds ratio [adjusted-OR], 2.4; 95% confidence interval [CI], 2.2-2.7; pConclusionHIV infection remained a significant risk for infectious respiratory diseases after the introduction of HAART, and infectious respiratory diseases were associated with an increased risk of mortality.