Structural Modification and Biological Activity of Polysaccharides
Ting Zhao,
Min Yang,
Lina Ma,
Xinglong Liu,
Qiteng Ding,
Guodong Chai,
Yang Lu,
Hewei Wei,
Shuai Zhang,
Chuanbo Ding
Affiliations
Ting Zhao
College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China
Min Yang
College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China
Lina Ma
College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China
Xinglong Liu
College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China
Qiteng Ding
Scientific and Technological Innovation Center of Health Products and Medical Materials with Characteristic Resources of Jilin Province, Jilin Agricultural University, Changchun 130118, China
Guodong Chai
Scientific and Technological Innovation Center of Health Products and Medical Materials with Characteristic Resources of Jilin Province, Jilin Agricultural University, Changchun 130118, China
Yang Lu
Scientific and Technological Innovation Center of Health Products and Medical Materials with Characteristic Resources of Jilin Province, Jilin Agricultural University, Changchun 130118, China
Hewei Wei
Scientific and Technological Innovation Center of Health Products and Medical Materials with Characteristic Resources of Jilin Province, Jilin Agricultural University, Changchun 130118, China
Shuai Zhang
Scientific and Technological Innovation Center of Health Products and Medical Materials with Characteristic Resources of Jilin Province, Jilin Agricultural University, Changchun 130118, China
Chuanbo Ding
College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China
Natural polysaccharides are macromolecular substances with a wide range of biological activities. The structural modification of polysaccharides by chemical means can enhance their biological activity. This paper reviews the latest research reports on the chemical modification of natural polysaccharides. At present, the modification methods of polysaccharides mainly include sulfation, phosphorylation, carboxymethylation, socialization, methylation and acetylation. The chemical and physical structures of the modified polysaccharides were detected via ultraviolet spectroscopy, FT-IR, high-performance liquid chromatography, ultraviolet spectroscopy, gas chromatography–mass spectrometry, nuclear magnetic resonance and scanning electron microscopy. Modern pharmacological studies have shown that the modified polysaccharide has various biological activities, such as antioxidant, antitumor, immune regulation, antiviral, antibacterial and anticoagulant functions in vitro. This review provides fresh ideas for the research and application of polysaccharide structure modification.
