Korean Journal of Pediatrics (Feb 2010)

High-dose caspofungin salvage in a very-low-birth-weight infant with refractory candidemia

  • Eun Sun Seo,
  • Geun Hwa Park,
  • Sung Mi Kim,
  • Hye An Jung,
  • Byoung Kuk Kim

DOI
https://doi.org/10.3345/kjp.2010.53.2.239
Journal volume & issue
Vol. 53, no. 2
pp. 239 – 243

Abstract

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Candidiasis is one of the most common causes of late-onset infection among very-low-birth-weight infants (VLBW) in most neonatal intensive care units and is associated with significant morbidity and mortality. Standard therapy consists of the administration of amphotericin B, amphotericin B complex, and fluconazole. In many cases, candidiasis is not easily eradicated, despite the administration of these drugs. We report our experience of the addition of high-dose caspofungin to the conventional antifungal drugs in a VLBW infant with refractory candidemia.