Nature Communications (Mar 2018)

HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns

  • Vaibhav P. Pai,
  • Alexis Pietak,
  • Valerie Willocq,
  • Bin Ye,
  • Nian-Qing Shi,
  • Michael Levin

DOI
https://doi.org/10.1038/s41467-018-03334-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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The authors have previously shown that membrane voltage can influence embryonic patterning during development. Here, the authors computationally model how nicotine disrupts Xenopus embryogenesis by perturbing voltage gradients, and rescue nicotine-inducted defects with HCN2 channel expression.