Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Kena Zhao; Tao Guo; Caifen Wang; Yong Zhou; Ting Xiong; Li Wu; Xue Li; Priyanka Mittal; Senlin Shi; Ruxandra Gref; Jiwen Zhang

Acta Pharmaceutica Sinica B (Sep 2020)

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Kena Zhao,
Tao Guo,
Caifen Wang,
Yong Zhou,
Ting Xiong,
Li Wu,
Xue Li,
Priyanka Mittal,
Senlin Shi,
Ruxandra Gref,
Jiwen Zhang

Affiliations

Kena Zhao: College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China; Center for Drug Delivery System, Shanghai Institute of Materia Medica, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai 201203, China
Tao Guo: Center for Drug Delivery System, Shanghai Institute of Materia Medica, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai 201203, China
Caifen Wang: Center for Drug Delivery System, Shanghai Institute of Materia Medica, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai 201203, China
Yong Zhou: Center for Drug Delivery System, Shanghai Institute of Materia Medica, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai 201203, China; Key Laboratory of Modern Chinese Medicine Preparations, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Ting Xiong: Center for Drug Delivery System, Shanghai Institute of Materia Medica, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai 201203, China; Key Laboratory of Modern Chinese Medicine Preparations, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Li Wu: Center for Drug Delivery System, Shanghai Institute of Materia Medica, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai 201203, China
Xue Li: Université Paris-Saclay, CNRS 8214, Institut des Sciences Moléculaires d'Orsay, Orsay 91405, France
Priyanka Mittal: Center for Drug Delivery System, Shanghai Institute of Materia Medica, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China
Senlin Shi: College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China; Corresponding authors. Tel./fax: +86 571 86613524 (Senlin Shi); +86 21 50805901 (Jiwen Zhang).
Ruxandra Gref: Université Paris-Saclay, CNRS 8214, Institut des Sciences Moléculaires d'Orsay, Orsay 91405, France; Corresponding authors. Tel./fax: +86 571 86613524 (Senlin Shi); +86 21 50805901 (Jiwen Zhang).
Jiwen Zhang: Center for Drug Delivery System, Shanghai Institute of Materia Medica, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai 201203, China; NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, National Institutes for Food and Drug Control, Beijing 100050, China; Key Laboratory of Modern Chinese Medicine Preparations, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; University of Chinese Academy of Sciences, Beijing 100049, China; Corresponding authors. Tel./fax: +86 571 86613524 (Senlin Shi); +86 21 50805901 (Jiwen Zhang).

Journal volume & issue: Vol. 10, no. 9
pp. 1709 – 1718

Abstract

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It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of γ-cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder inhalers (DPIs) carrier with high fine particle fraction (FPF), it was found in this research that the encapsulation of a glycoside compound, namely, scutellarin (SCU) in CD-MOF could significantly enhance its laryngeal deposition. Firstly, SCU loading into CD-MOF was optimized by incubation. Then, a series of characterizations were carried out to elucidate the mechanisms of drug loading. Finally, the laryngeal deposition rate of CD-MOF was 57.72 ± 2.19% improved by SCU, about two times higher than that of CD-MOF, when it was determined by Next Generation Impactor (NGI) at 65 L/min. As a proof of concept, pharyngolaryngitis therapeutic agent dexamethasone (DEX) had improved laryngeal deposition after being co-encapsulated with SCU in CD-MOF. The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF, which defined the enhanced laryngeal anchoring. In conclusion, the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.

Published in Acta Pharmaceutica Sinica B

ISSN: 2211-3835 (Print); 2211-3843 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/acta-pharmaceutica-sinica-b

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