Case Reports in Pathology (Jan 2021)

A Review Leveraging a Rare and Unusual Case of Basal Cell Carcinoma of the Prostate

  • Lin He,
  • Christopher Metter,
  • Vitaly Margulis,
  • Payal Kapur

DOI
https://doi.org/10.1155/2021/5520581
Journal volume & issue
Vol. 2021

Abstract

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Basal cell carcinoma (BCC) is a rare nonacinar variant of prostatic carcinoma. In spite of prostatic acinar adenocarcinoma being one of the most common carcinomas in prostate, <100 prostatic BCC cases have been reported to date. Adenoid cystic/cribriform histology has been described in varying proportions to occur in prostatic BCC and is reported to be associated with aggressive behavior and high risk of metastasis. Herein, we present a case of prostatic BCC with adenoid cystic morphology, comprehensively describe its immunohistochemical and MYB/MYBL1 gene rearrangement findings, discuss its differential diagnosis, and review the literature of this rare entity.