Enzymatic one-step ring contraction for quinolone biosynthesis

Shinji Kishimoto; Kodai Hara; Hiroshi Hashimoto; Yuichiro Hirayama; Pier Alexandre Champagne; Kendall N. Houk; Yi Tang; Kenji Watanabe

doi:10.1038/s41467-018-05221-5

Nature Communications (Jul 2018)

Enzymatic one-step ring contraction for quinolone biosynthesis

Shinji Kishimoto,
Kodai Hara,
Hiroshi Hashimoto,
Yuichiro Hirayama,
Pier Alexandre Champagne,
Kendall N. Houk,
Yi Tang,
Kenji Watanabe

Affiliations

Shinji Kishimoto: Department of Pharmaceutical Sciences, University of Shizuoka
Kodai Hara: Department of Pharmaceutical Sciences, University of Shizuoka
Hiroshi Hashimoto: Department of Pharmaceutical Sciences, University of Shizuoka
Yuichiro Hirayama: Department of Pharmaceutical Sciences, University of Shizuoka
Pier Alexandre Champagne: Department of Chemistry and Biochemistry, University of California
Kendall N. Houk: Department of Chemistry and Biochemistry, University of California
Yi Tang: Department of Chemistry and Biochemistry, University of California
Kenji Watanabe: Department of Pharmaceutical Sciences, University of Shizuoka

DOI: https://doi.org/10.1038/s41467-018-05221-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 7

Abstract

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Viridicatin is a fungal alkaloid. Here, the authors identify and characterize the cyclopenase that catalyzes the last step of its biosynthesis in Aspergillus nidulans, the conversion of cyclopenin to viridicatin, and find that the reaction proceeds via an unusual elimination mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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