Antioxidants (Feb 2023)

Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease

  • Elena Dozio,
  • Lara Caldiroli,
  • Paolo Molinari,
  • Giuseppe Castellano,
  • Nicholas Walter Delfrate,
  • Massimiliano Marco Corsi Romanelli,
  • Simone Vettoretti

DOI
https://doi.org/10.3390/antiox12030584
Journal volume & issue
Vol. 12, no. 3
p. 584

Abstract

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Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. The aim of this review is to summarize the present knowledge of AGEs in CKD onset and progression, also focusing on CKD-related disorders (cardiovascular diseases, sarcopenia, and nutritional imbalance) and CKD mortality. The role of AGEs as etiopathogenetic molecules, as well as potential markers of disease progression and/or therapeutic targets, will be discussed.

Keywords