Nature Communications (Mar 2021)
The essential role of PRAK in tumor metastasis and its therapeutic potential
- Yuqing Wang,
- Wei Wang,
- Haoming Wu,
- Yu Zhou,
- Xiaodan Qin,
- Yan Wang,
- Jia Wu,
- Xiu-Yuan Sun,
- Yan Yang,
- Hui Xu,
- Xiaoping Qian,
- Xuewen Pang,
- Yan Li,
- Zhiqian Zhang,
- Jiahuai Han,
- Yu Zhang
Affiliations
- Yuqing Wang
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Wei Wang
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Haoming Wu
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Yu Zhou
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Xiaodan Qin
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Yan Wang
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Jia Wu
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Xiu-Yuan Sun
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Yan Yang
- Institute of Biological Sciences, Jinzhou Medical University
- Hui Xu
- Institute of Biological Sciences, Jinzhou Medical University
- Xiaoping Qian
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Xuewen Pang
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Yan Li
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- Zhiqian Zhang
- Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cell Biology, Peking University Cancer Hospital and Institute
- Jiahuai Han
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Yu Zhang
- Department of Immunology, School of Basic Medical Sciences, Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
- DOI
- https://doi.org/10.1038/s41467-021-21993-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Metastasis is one of the leading causes of cancer-related death. Here, the authors report a pro-metastatic role of PRAK in breast cancer lung metastasis via a mechanism involving enhanced HIF-1α translation, and propose PRAK targeting as a strategy to treat metastasis.
