Broad CD8+ T cell cross-recognition of distinct influenza A strains in humans

Emma J. Grant; Tracy M. Josephs; Liyen Loh; E. Bridie Clemens; Sneha Sant; Mandvi Bharadwaj; Weisan Chen; Jamie Rossjohn; Stephanie Gras; Katherine Kedzierska

doi:10.1038/s41467-018-07815-5

Nature Communications (Dec 2018)

Broad CD8+ T cell cross-recognition of distinct influenza A strains in humans

Emma J. Grant,
Tracy M. Josephs,
Liyen Loh,
E. Bridie Clemens,
Sneha Sant,
Mandvi Bharadwaj,
Weisan Chen,
Jamie Rossjohn,
Stephanie Gras,
Katherine Kedzierska

Affiliations

Emma J. Grant: Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Tracy M. Josephs: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Liyen Loh: Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
E. Bridie Clemens: Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Sneha Sant: Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Mandvi Bharadwaj: Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Weisan Chen: Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University
Jamie Rossjohn: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Stephanie Gras: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Katherine Kedzierska: Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity

DOI: https://doi.org/10.1038/s41467-018-07815-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Mutations within immunological epitope containing regions of influenza A virus can impair the established immune response between influenza strains and could impact rational vaccine design. Here Grant et al. examine the presence, structural impact and cross reactivity of two human immunodominant influenza epitope variants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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