The importance of overcoming the challenges in delivering the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment (PURSUIT) study
Caroline Pope,
Nikki Cotterill,
Marcus J. Drake,
Beth Fitzgerald,
Tamsin Greenwell,
Swati Jha,
J. Athene Lane,
Stephanie J. MacNeill,
Sangeetha Paramasivan,
Wael Agur,
Alison White
Affiliations
Caroline Pope
Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Bristol Trials Centre, University of Bristol, Bristol, UK
Nikki Cotterill
Faculty of Health and Applied Sciences, School of Health and Social Wellbeing, University of the West of England, Bristol, UK; Bristol Urological Institute, Southmead Hospital, Bristol, UK
Marcus J. Drake
Bristol Urological Institute, Southmead Hospital, Bristol, UK; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Corresponding author at: Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Beth Fitzgerald
Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
Tamsin Greenwell
Department of Urology, University College London Hospital, London, UK
Swati Jha
Sheffield Teaching Hospitals, NHS Foundation Trust, UK
J. Athene Lane
Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Bristol Trials Centre, University of Bristol, Bristol, UK
Stephanie J. MacNeill
Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Bristol Trials Centre, University of Bristol, Bristol, UK
Sangeetha Paramasivan
Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Bristol Trials Centre, University of Bristol, Bristol, UK
Wael Agur
School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK; University Hospital Crosshouse, NHS Ayrshire and Arran, Kilmarnock, UK
Alison White
Patient and Public Involvement (PPI) Representative, University of Bristol, Bristol, UK
There is insufficient data to assess the effects of any of the different management strategies for recurrent or persistent stress urinary incontinence in women after failed interventional treatment. The evidence base lacks well-designed randomised trials with sufficient power to answer this hugely important issue. PURSUIT is the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment study, assessing through randomisation whether endoscopic or surgical interventions achieve better cure and/or quality of life outcomes at 1 year, and will follow up to 3 years to see if responses are sustained. The manuscript provides an outline of the study, describes the challenges it has faced, and advocates the importance of ensuring its successful delivery.
