Nature Communications (Nov 2016)

17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells

  • Benjamin Joachim Schmiedel,
  • Grégory Seumois,
  • Daniela Samaniego-Castruita,
  • Justin Cayford,
  • Veronique Schulten,
  • Lukas Chavez,
  • Ferhat Ay,
  • Alessandro Sette,
  • Bjoern Peters,
  • Pandurangan Vijayanand

DOI
https://doi.org/10.1038/ncomms13426
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

Variations in the 17q21 locus are linked to asthma susceptibility and other autoimmune diseases. Here, the authors perform cell type-specific functional genomic analyses of asthma-risk SNPs, and show a genotype specific mechanism of differential gene regulation relevant to immune function.