Association of Quantitative and Qualitative Dermatoglyphic Variable and DNA Polymorphism in Female Breast Cancer Population

Abstract

Objective: To investigate the association between dermatoglyphics and the DNA repair genetic variants in female breast carcinoma. Methodology: The distinct dermatoglyphic variables include ≥ six whorls, Finger ridge counts, A-B Ridge Count, ATD angle and Pattern intensity Index are analyzed for its association with the DNA repair variants namely XRCC1 Arg194Trp, XRCC3Thr241Met, ERCC4Arg 415Gln, and ERCC5 Asp1104His. The statistical procedure used to analyze the frequency of association is odds ratio and relative risk ratio. Result:The results suggests that the relative risk is about 2 to 4 times with statistical significance for breast cancer and high risk group for the genes XRCC1 Arg194Trp, ERCC4 Arg 415 Gln, ERCC5 Asp1104His in their dominant model in both breast cancer and high risk group for six or more whorls, Pattern Intensity Index, A-B RC. Conclusion: It can be suggested that dermal ridges can be used as an effective biomarker of genomic instability in breast cancer.

Keywords

• Dermatoglyphics
• DNA repair gene
• single nucleotide polymorphism
• breast cancer
• genetic instability