Nature Communications (Oct 2022)
Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors
- Sayaka Oda,
- Kazuhiro Nishiyama,
- Yuka Furumoto,
- Yohei Yamaguchi,
- Akiyuki Nishimura,
- Xiaokang Tang,
- Yuri Kato,
- Takuro Numaga-Tomita,
- Toshiyuki Kaneko,
- Supachoke Mangmool,
- Takuya Kuroda,
- Reishin Okubo,
- Makoto Sanbo,
- Masumi Hirabayashi,
- Yoji Sato,
- Yasuaki Nakagawa,
- Koichiro Kuwahara,
- Ryu Nagata,
- Gentaro Iribe,
- Yasuo Mori,
- Motohiro Nishida
Affiliations
- Sayaka Oda
- National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences
- Kazuhiro Nishiyama
- Graduate School of Pharmaceutical Sciences, Kyushu University
- Yuka Furumoto
- Graduate School of Pharmaceutical Sciences, Kyushu University
- Yohei Yamaguchi
- Asahikawa Medical University
- Akiyuki Nishimura
- National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences
- Xiaokang Tang
- National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences
- Yuri Kato
- Graduate School of Pharmaceutical Sciences, Kyushu University
- Takuro Numaga-Tomita
- National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences
- Toshiyuki Kaneko
- Asahikawa Medical University
- Supachoke Mangmool
- Faculty of Science, Mahidol University
- Takuya Kuroda
- National Institute of Health Sciences
- Reishin Okubo
- Graduate School of Pharmaceutical Sciences, Kyushu University
- Makoto Sanbo
- National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences
- Masumi Hirabayashi
- National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences
- Yoji Sato
- National Institute of Health Sciences
- Yasuaki Nakagawa
- Kyoto University Graduate School of Medicine
- Koichiro Kuwahara
- Shinshu University School of Medicine
- Ryu Nagata
- Graduate School of Pharmaceutical Sciences, Osaka University
- Gentaro Iribe
- Asahikawa Medical University
- Yasuo Mori
- Graduate School of Engineering, Kyoto University
- Motohiro Nishida
- National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences
- DOI
- https://doi.org/10.1038/s41467-022-34194-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Baroreflex control of cardiac contractility is essential to maintain cardiocirculatory homeostasis. Here, Oda et al show that α1 adrenoceptor-stimulated Zn2+ entry through TRPC6 channels boosts β adrenoceptor-dependent myocardial positive inotropy.
