Nature Communications (Apr 2018)
Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies
- Mette Boyd,
- Malte Thodberg,
- Morana Vitezic,
- Jette Bornholdt,
- Kristoffer Vitting-Seerup,
- Yun Chen,
- Mehmet Coskun,
- Yuan Li,
- Bobby Zhao Sheng Lo,
- Pia Klausen,
- Pawel Jan Schweiger,
- Anders Gorm Pedersen,
- Nicolas Rapin,
- Kerstin Skovgaard,
- Katja Dahlgaard,
- Robin Andersson,
- Thilde Bagger Terkelsen,
- Berit Lilje,
- Jesper Thorvald Troelsen,
- Andreas Munk Petersen,
- Kim Bak Jensen,
- Ismail Gögenur,
- Peter Thielsen,
- Jakob Benedict Seidelin,
- Ole Haagen Nielsen,
- Jacob Tveiten Bjerrum,
- Albin Sandelin
Affiliations
- Mette Boyd
- Department of Biology, University of Copenhagen
- Malte Thodberg
- Department of Biology, University of Copenhagen
- Morana Vitezic
- Department of Biology, University of Copenhagen
- Jette Bornholdt
- Department of Biology, University of Copenhagen
- Kristoffer Vitting-Seerup
- Department of Biology, University of Copenhagen
- Yun Chen
- Department of Biology, University of Copenhagen
- Mehmet Coskun
- Department of Biology, University of Copenhagen
- Yuan Li
- Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen
- Bobby Zhao Sheng Lo
- Department of Biology, University of Copenhagen
- Pia Klausen
- Department of Gastroenterology, Surgical Section, Herlev Hospital
- Pawel Jan Schweiger
- Biotech Research and Innovation Centre, University of Copenhagen
- Anders Gorm Pedersen
- DTU Bioinformatics, Technical University of Denmark
- Nicolas Rapin
- Biotech Research and Innovation Centre, University of Copenhagen
- Kerstin Skovgaard
- Department of Biotechnology and Biomedicine, Technical University of Denmark
- Katja Dahlgaard
- Department of Science and Environment (INM), Roskilde University
- Robin Andersson
- Department of Biology, University of Copenhagen
- Thilde Bagger Terkelsen
- Department of Biology, University of Copenhagen
- Berit Lilje
- Department of Biology, University of Copenhagen
- Jesper Thorvald Troelsen
- Department of Science and Environment (INM), Roskilde University
- Andreas Munk Petersen
- Hvidovre Hospital, Gastrounit Medical Division, University of Copenhagen
- Kim Bak Jensen
- Biotech Research and Innovation Centre, University of Copenhagen
- Ismail Gögenur
- Centre for Surgical Science, Department of Surgery, Zealand University Hospital
- Peter Thielsen
- Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen
- Jakob Benedict Seidelin
- Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen
- Ole Haagen Nielsen
- Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen
- Jacob Tveiten Bjerrum
- Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen
- Albin Sandelin
- Department of Biology, University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-018-03766-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 19
Abstract
Many SNPs associated with inflammatory bowel disease are located in non-coding genomic regions. Here, the authors perform CAGE-sequencing on descending colon biopsies of Crohn’s disease and ulcerative colitis patients to map transcription start sites and enhancer activity for analysis of regulatory regions.
