Single cell transcriptomics of human epidermis identifies basal stem cell transition states

Shuxiong Wang; Michael L. Drummond; Christian F. Guerrero-Juarez; Eric Tarapore; Adam L. MacLean; Adam R. Stabell; Stephanie C. Wu; Guadalupe Gutierrez; Bao T. That; Claudia A. Benavente; Qing Nie; Scott X. Atwood

doi:10.1038/s41467-020-18075-7

Nature Communications (Aug 2020)

Single cell transcriptomics of human epidermis identifies basal stem cell transition states

Shuxiong Wang,
Michael L. Drummond,
Christian F. Guerrero-Juarez,
Eric Tarapore,
Adam L. MacLean,
Adam R. Stabell,
Stephanie C. Wu,
Guadalupe Gutierrez,
Bao T. That,
Claudia A. Benavente,
Qing Nie,
Scott X. Atwood

Affiliations

Shuxiong Wang: Department of Developmental and Cell Biology, University of California, Irvine
Michael L. Drummond: Department of Developmental and Cell Biology, University of California, Irvine
Christian F. Guerrero-Juarez: Department of Developmental and Cell Biology, University of California, Irvine
Eric Tarapore: Department of Developmental and Cell Biology, University of California, Irvine
Adam L. MacLean: Department of Mathematics, University of California, Irvine
Adam R. Stabell: Department of Developmental and Cell Biology, University of California, Irvine
Stephanie C. Wu: Department of Developmental and Cell Biology, University of California, Irvine
Guadalupe Gutierrez: Department of Developmental and Cell Biology, University of California, Irvine
Bao T. That: Department of Developmental and Cell Biology, University of California, Irvine
Claudia A. Benavente: Department of Developmental and Cell Biology, University of California, Irvine
Qing Nie: Department of Developmental and Cell Biology, University of California, Irvine
Scott X. Atwood: Department of Developmental and Cell Biology, University of California, Irvine

DOI: https://doi.org/10.1038/s41467-020-18075-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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The mechanisms regulating stem cells to give rise to human interfollicular epidermis are unclear. Here, the authors use single cell RNA sequencing to identify heterogeneity within the human neonatal interfollicular epidermis and distinct spatial positioning of at least four basal stem cell populations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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