Relationship between the Soluble F11 Receptor and Annexin A5 in African Americans Patients with Type-2 Diabetes Mellitus
Ajibola Adedayo,
Ayobami Eluwole,
Fasika Tedla,
Arye Kremer,
Muhammad Khan,
Nicole Mastrogiovanni,
Carl Rosenberg,
Paul Dreizen,
John La Rosa,
Louis Salciccioli,
Mohamed Boutjdir,
Mary Ann Banerji,
Clinton Brown,
Jason Lazar,
Moro Salifu,
Ahmed Bakillah
Affiliations
Ajibola Adedayo
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Ayobami Eluwole
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Fasika Tedla
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Arye Kremer
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Muhammad Khan
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Nicole Mastrogiovanni
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Carl Rosenberg
Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Paul Dreizen
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
John La Rosa
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Louis Salciccioli
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Mohamed Boutjdir
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Mary Ann Banerji
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Clinton Brown
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Jason Lazar
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Moro Salifu
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Ahmed Bakillah
Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA
Type 2 diabetes mellitus (T2DM) is characterized by endothelial dysfunction, increased thrombogenicity, and inflammation. The soluble human F11 receptor (sF11R) and annexin A5 (ANXA5) play crucial roles in inflammatory thrombosis and atherosclerosis. We examined the relationship between circulating sF11R and ANXA5 and their impact on endothelial function. The study included 125 patients with T2DM. Plasma levels of sF11R and ANXA5 were quantified by ELISA. Microvascular function was assessed using the vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound imaging. The mean age of patients in the study was 59.7 ± 7.8 years, 78% had hypertension, 76% had dyslipidemia, and 12% had CKD. sF11R correlated positively with ANXA5 levels (β = 0.250, p = 0.005), and correlated inversely with VRI and total nitic oxide (NO), (β = −0.201, p = 0.024; β = −0.357, p = 0.0001, respectively). Multivariate regression analysis revealed that sF11R was independently associated with ANXA5 in the total population and in patients with HbA1c > 6.5% (β = 0.366, p = 0.007; β = 0.425, p = 0.0001, respectively). sF11R and ANXA5 were not associated with vascular outcome, suggesting that they may not be reliable markers of vascular dysfunction in diabetes. The clinical significance of sF11R/ANXA5 association in diabetes warrants further investigation in a larger population.
