Nature Communications (Dec 2022)
Genetic architecture of heart failure with preserved versus reduced ejection fraction
- Jacob Joseph,
- Chang Liu,
- Qin Hui,
- Krishna Aragam,
- Zeyuan Wang,
- Brian Charest,
- Jennifer E. Huffman,
- Jacob M. Keaton,
- Todd L. Edwards,
- Serkalem Demissie,
- Luc Djousse,
- Juan P. Casas,
- J. Michael Gaziano,
- Kelly Cho,
- Peter W. F. Wilson,
- Lawrence S. Phillips,
- VA Million Veteran Program,
- Christopher J. O’Donnell,
- Yan V. Sun
Affiliations
- Jacob Joseph
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Chang Liu
- Emory University Rollins School of Public Health
- Qin Hui
- Emory University Rollins School of Public Health
- Krishna Aragam
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Zeyuan Wang
- Emory University Rollins School of Public Health
- Brian Charest
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Jennifer E. Huffman
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Jacob M. Keaton
- Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health
- Todd L. Edwards
- Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center
- Serkalem Demissie
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Luc Djousse
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Juan P. Casas
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- J. Michael Gaziano
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Kelly Cho
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Peter W. F. Wilson
- Atlanta VA Health Care System
- Lawrence S. Phillips
- Atlanta VA Health Care System
- VA Million Veteran Program
- Christopher J. O’Donnell
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Yan V. Sun
- Emory University Rollins School of Public Health
- DOI
- https://doi.org/10.1038/s41467-022-35323-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
While the genetic basis of heart failure has been explored by genetic studies, the differences between subtypes are not well understood. Here, the authors performed genetic analyses on the two major subtypes of heart failure in a large biobank with genetic and health record data, finding unique genetic architecture for each subtype.
