OPTIMIZATION OF PATIENTS MANAGEMENT IN MYOCARDIAL INFARCTION COMORBIDITY WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Abstract

Aim. To investigate on the efficacy of thiotriazoline (TTZ) in complex management of acute myocardial infarction (AMI) patients with hepatic steatosis.Material and methods. Totally, 32 left ventricle AMI patients included, comorbid with non-alcoholic fatty liver disease. Assessment of electrical activity of myocardium was done on improved polygraph with electroand vectorcardiogram registration before and post three week basic therapy in 16 patients (13 males and 3 females, mean age — 60,5±3,74 y.o.) and management with added TTZ (8 males and 8 females, mean age – 62,94±2,71 y.o.).Results. On basic therapy, there was ongoing decline in electromotive force of the heart with slower impulse conduction and disordered repolarization in atrial myocardium, with decreasing area of damage in the left ventricle and atrial overload. Concomitant TTZ usage with basic therapy led to minimal positive shifts in electromotive force of the heart. Also, there was increase of ischemia zone due to decrease of myocardial damage area, more prominent normalization of left atrium compartment and stabilization of repolarization processes in atria.Conclusion. Under the combination treatment by TTZ there was significant change of the grade of electrical activity of the heart electrical activity disorder comparing to basic therapy.

Keywords

• acute period of myocardial infarction
• non-alcoholic fatty liver disease
• vectorcardiography
• thiotraizoline