Phenytoin and Carbamazepine Teratogenicity

Abstract

In a prospective, controlled, and blinded study of 36 mother-child pairs exposed to carbamazepine (CBZ) monotherapy, 34 pairs exposed to phenytoin (DPH) monotherapy, and 9 nonmedicated epileptic women and their children, the patterns of malformations in the children exposed to potential teratogenic factors were compared with matched mother-child pairs exposed to nonteratogens, at the Hospital for Sick Children, Toronto, Canada.

Keywords

• phenytoin monotherapy
• carbamazepine monotherapy
• spina bifida