Nature Communications (Aug 2022)
Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection
- Khadija Khan,
- Farina Karim,
- Yashica Ganga,
- Mallory Bernstein,
- Zesuliwe Jule,
- Kajal Reedoy,
- Sandile Cele,
- Gila Lustig,
- Daniel Amoako,
- Nicole Wolter,
- Natasha Samsunder,
- Aida Sivro,
- James Emmanuel San,
- Jennifer Giandhari,
- Houriiyah Tegally,
- Sureshnee Pillay,
- Yeshnee Naidoo,
- Matilda Mazibuko,
- Yoliswa Miya,
- Nokuthula Ngcobo,
- Nithendra Manickchund,
- Nombulelo Magula,
- Quarraisha Abdool Karim,
- Anne von Gottberg,
- Salim S. Abdool Karim,
- Willem Hanekom,
- Bernadett I. Gosnell,
- COMMIT-KZN Team,
- Richard J. Lessells,
- Tulio de Oliveira,
- Mahomed-Yunus S. Moosa,
- Alex Sigal
Affiliations
- Khadija Khan
- Africa Health Research Institute
- Farina Karim
- Africa Health Research Institute
- Yashica Ganga
- Africa Health Research Institute
- Mallory Bernstein
- Africa Health Research Institute
- Zesuliwe Jule
- Africa Health Research Institute
- Kajal Reedoy
- Africa Health Research Institute
- Sandile Cele
- Africa Health Research Institute
- Gila Lustig
- Centre for the AIDS Programme of Research in South Africa
- Daniel Amoako
- National Institute for Communicable Diseases of the National Health Laboratory Service
- Nicole Wolter
- National Institute for Communicable Diseases of the National Health Laboratory Service
- Natasha Samsunder
- Centre for the AIDS Programme of Research in South Africa
- Aida Sivro
- Centre for the AIDS Programme of Research in South Africa
- James Emmanuel San
- KwaZulu-Natal Research Innovation and Sequencing Platform
- Jennifer Giandhari
- KwaZulu-Natal Research Innovation and Sequencing Platform
- Houriiyah Tegally
- KwaZulu-Natal Research Innovation and Sequencing Platform
- Sureshnee Pillay
- KwaZulu-Natal Research Innovation and Sequencing Platform
- Yeshnee Naidoo
- KwaZulu-Natal Research Innovation and Sequencing Platform
- Matilda Mazibuko
- Africa Health Research Institute
- Yoliswa Miya
- Africa Health Research Institute
- Nokuthula Ngcobo
- Africa Health Research Institute
- Nithendra Manickchund
- Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal
- Nombulelo Magula
- Division of Internal Medicine, Nelson R. Mandela School of Medicine, University of Kwa-Zulu Natal
- Quarraisha Abdool Karim
- Centre for the AIDS Programme of Research in South Africa
- Anne von Gottberg
- National Institute for Communicable Diseases of the National Health Laboratory Service
- Salim S. Abdool Karim
- Centre for the AIDS Programme of Research in South Africa
- Willem Hanekom
- Africa Health Research Institute
- Bernadett I. Gosnell
- Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal
- COMMIT-KZN Team
- Richard J. Lessells
- KwaZulu-Natal Research Innovation and Sequencing Platform
- Tulio de Oliveira
- KwaZulu-Natal Research Innovation and Sequencing Platform
- Mahomed-Yunus S. Moosa
- Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal
- Alex Sigal
- Africa Health Research Institute
- DOI
- https://doi.org/10.1038/s41467-022-32396-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 7
Abstract
Emerging SARS-CoV-2 Omicron sub-lineages BA.4 and BA.5 raise concerns about potential immune evasion. Here, Khan et al. show that both BA.4 and BA.5 are able to escape immune response induced by prior BA.1 infection, but that this effect is less pronounced in vaccinated individuals.
