Frontiers in Medicine (Mar 2023)

The relationship between triglyceride, cholesterol and lipoprotein levels, and immune responses to hepatitis B vaccine

  • Dan Guo,
  • Jiazhen Dai,
  • Rong Ju,
  • Qifan Zhou,
  • Nenghuan Wang,
  • Chunhua Wu,
  • Hui Tao,
  • Hui Jing,
  • Chen Zhu,
  • Jinxian Mao,
  • Jiayan Xu

DOI
https://doi.org/10.3389/fmed.2023.1131373
Journal volume & issue
Vol. 10

Abstract

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Cholesterol homeostasis disorder and hypertriglyceridemia, as common metabolic conditions, have rarely been reported to affect the immune responses to the hepatitis B vaccine. Our study found that higher high-density lipoprotein (HDL) level showed a significant relationship with positive anti-HBs results (cOR = 1.479, 95% CI: 1.150, 1.901, p = 0.002; aOR = 1.304, 95% CI: 1.006, 1.691, p = 0.045), especially in individuals aged 18- to 40-year-old, female, smoking more than 100 cigarettes in life, and drinking more than 12 times every year. Lower low-density lipoprotein (LDL) level was associated with a negative anti-HBs result among participants aged 18- to 40-year-old, and participants who were obese. Higher level of HDL and lower level of LDL may be protective factors of better immune effect of hepatitis B vaccine. More research should be conducted to investigate the influence of the cholesterol level on the immune responses to the hepatitis B vaccine, and more in-depth research should be performed to uncover the mechanism.

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