Electrical modulation of transplanted stem cells improves functional recovery in a rodent model of stroke

Byeongtaek Oh; Sruthi Santhanam; Matine Azadian; Vishal Swaminathan; Alex G. Lee; Kelly W. McConnell; Alexa Levinson; Shang Song; Jainith J. Patel; Emily E. Gardner; Paul M. George

doi:10.1038/s41467-022-29017-w

Nature Communications (Mar 2022)

Electrical modulation of transplanted stem cells improves functional recovery in a rodent model of stroke

Byeongtaek Oh,
Sruthi Santhanam,
Matine Azadian,
Vishal Swaminathan,
Alex G. Lee,
Kelly W. McConnell,
Alexa Levinson,
Shang Song,
Jainith J. Patel,
Emily E. Gardner,
Paul M. George

Affiliations

Byeongtaek Oh: Department of Neurology and Neurological Sciences, Stanford University School of Medicine
Sruthi Santhanam: Department of Neurology and Neurological Sciences, Stanford University School of Medicine
Matine Azadian: Department of Neurology and Neurological Sciences, Stanford University School of Medicine
Vishal Swaminathan: Department of Neurology and Neurological Sciences, Stanford University School of Medicine
Alex G. Lee: Department of Pediatrics, University of California
Kelly W. McConnell: Department of Neurology and Neurological Sciences, Stanford University School of Medicine
Alexa Levinson: Department of Neurology and Neurological Sciences, Stanford University School of Medicine
Shang Song: Department of Neurology and Neurological Sciences, Stanford University School of Medicine
Jainith J. Patel: Department of Neurology and Neurological Sciences, Stanford University School of Medicine
Emily E. Gardner: Department of Neurology and Neurological Sciences, Stanford University School of Medicine
Paul M. George: Department of Neurology and Neurological Sciences, Stanford University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-29017-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Paul George and colleagues developed a conductive polymer system to enable stem cell delivery and electrical modulation in vivo. Employing this system improved functional stroke recovery in rodents and identified important repair pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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