Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Samuel A. J. Trammell; Mark S. Schmidt; Benjamin J. Weidemann; Philip Redpath; Frank Jaksch; Ryan W. Dellinger; Zhonggang Li; E. Dale Abel; Marie E. Migaud; Charles Brenner

doi:10.1038/ncomms12948

Nature Communications (Oct 2016)

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Samuel A. J. Trammell,
Mark S. Schmidt,
Benjamin J. Weidemann,
Philip Redpath,
Frank Jaksch,
Ryan W. Dellinger,
Zhonggang Li,
E. Dale Abel,
Marie E. Migaud,
Charles Brenner

Affiliations

Samuel A. J. Trammell: Department of Biochemistry, Carver College of Medicine, University of Iowa
Mark S. Schmidt: Department of Biochemistry, Carver College of Medicine, University of Iowa
Benjamin J. Weidemann: Department of Biochemistry, Carver College of Medicine, University of Iowa
Philip Redpath: John King Laboratory, School of Pharmacy, Queens University Belfast
Frank Jaksch: ChromaDex, Inc.
Ryan W. Dellinger: ChromaDex, Inc.
Zhonggang Li: Department of Internal Medicine, Carver College of Medicine, University of Iowa
E. Dale Abel: Department of Biochemistry, Carver College of Medicine, University of Iowa
Marie E. Migaud: Department of Biochemistry, Carver College of Medicine, University of Iowa
Charles Brenner: Department of Biochemistry, Carver College of Medicine, University of Iowa

DOI: https://doi.org/10.1038/ncomms12948
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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NAD+ is an important coenzyme that mediates cellular metabolism and defends against stresses due to age and overnutrition. Here the authors demonstrate unique bioavailability of the NAD+ precursor vitamin nicotinamide riboside (NR) in mice and humans, and show that NR safely elevates human NAD+.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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