Kaohsiung Journal of Medical Sciences (Feb 2024)
Pretreatment gamma‐glutamyl transferase predicts mortality in patients with chronic hepatitis B treated with nucleotide/nucleoside analogs
- Tyng‐Yuan Jang,
- Po‐Cheng Liang,
- Dae Won Jun,
- Jang Han Jung,
- Hidenori Toyoda,
- Chih‐Wen Wang,
- Man‐Fung Yuen,
- Ka Shing Cheung,
- Satoshi Yasuda,
- Sung Eun Kim,
- Eileen L. Yoon,
- Jihyun An,
- Masaru Enomoto,
- Ritsuzo Kozuka,
- Makoto Chuma,
- Akito Nozaki,
- Toru Ishikawa,
- Tsunamasa Watanabe,
- Masanori Atsukawa,
- Taeang Arai,
- Korenobu Hayama,
- Masatoshi Ishigami,
- Yong Kyun Cho,
- Eiichi Ogawa,
- Hyoung Su Kim,
- Jae‐Jun Shim,
- Haruki Uojima,
- Soung Won Jeong,
- Sang Bong Ahn,
- Koichi Takaguchi,
- Tomonori Senoh,
- Maria Buti,
- Elena Vargas‐Accarino,
- Hiroshi Abe,
- Hirokazu Takahashi,
- Kaori Inoue,
- Jee‐Fu Huang,
- Wan‐Long Chuang,
- Ming‐Lun Yeh,
- Chia‐Yen Dai,
- Chung‐Feng Huang,
- Mindie H. Nguyen,
- Ming‐Lung Yu
Affiliations
- Tyng‐Yuan Jang
- Ph.D. Program in Environmental and Occupational Medicine, College of Medicine Kaohsiung Medical University and National Health Research Institutes Kaohsiung Taiwan
- Po‐Cheng Liang
- Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan
- Dae Won Jun
- Department of Internal Medicine Hanyang University Hospital, Hanyang University College of Medicine Seoul South Korea
- Jang Han Jung
- Division of Gastroenterology, Department of Internal Medicine Severance Hospital, Yonsei University College of Medicine Seoul Korea
- Hidenori Toyoda
- Department of Gastroenterology and Hepatology Ogaki Municipal Hospital Gifu Japan
- Chih‐Wen Wang
- Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan
- Man‐Fung Yuen
- Department of Medicine School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong Hong Kong Hong Kong
- Ka Shing Cheung
- Department of Medicine School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong Hong Kong Hong Kong
- Satoshi Yasuda
- Department of Gastroenterology and Hepatology Ogaki Municipal Hospital Gifu Japan
- Sung Eun Kim
- Department of Internal Medicine Hallym University Sacred Heart Hospital, Hallym University College of Medicine Anyang South Korea
- Eileen L. Yoon
- Department of Internal Medicine Hanyang University Hospital, Hanyang University College of Medicine Seoul South Korea
- Jihyun An
- Department of Internal Medicine Hanyang University College of Medicine, Hanyang University Guri Hospital Guri South Korea
- Masaru Enomoto
- Department of Hepatology Graduate School of Medicine, Osaka Metropolitan University Osaka Japan
- Ritsuzo Kozuka
- Department of Hepatology Graduate School of Medicine, Osaka Metropolitan University Osaka Japan
- Makoto Chuma
- Gastroenterological Center Yokohama City University Medical Center Yokohama Japan
- Akito Nozaki
- Gastroenterological Center Yokohama City University Medical Center Yokohama Japan
- Toru Ishikawa
- Department of Gastroenterology Saiseikai Niigata Hospital Niigata Japan
- Tsunamasa Watanabe
- Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
- Masanori Atsukawa
- Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan
- Taeang Arai
- Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan
- Korenobu Hayama
- Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan
- Masatoshi Ishigami
- Department of Gastroenterology & Hepatology Nagoya University Graduate School of Medicine Nagoya Japan
- Yong Kyun Cho
- Department of Internal Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine Seoul South Korea
- Eiichi Ogawa
- Department of General Internal Medicine Kyushu University Kyushu Japan
- Hyoung Su Kim
- Department of Internal Medicine Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine Seoul South Korea
- Jae‐Jun Shim
- Department of Internal Medicine Kyung Hee University Hospital, Kyung Hee University School of Medicine Seoul South Korea
- Haruki Uojima
- Department of Gastroenterology Internal Medicine, Kitasato University School of Medicine Sagamihara Japan
- Soung Won Jeong
- Department of Internal Medicine Soonchunhyang University Hospital, Soonchunhyang University College of Medicine Seoul South Korea
- Sang Bong Ahn
- Department of Internal Medicine Nowon Eulji Medical Center, Eulji University College of Medicine Seoul South Korea
- Koichi Takaguchi
- Department of Hepatology Kagawa Prefectural Central Hospital Kagawa Japan
- Tomonori Senoh
- Department of Hepatology Kagawa Prefectural Central Hospital Kagawa Japan
- Maria Buti
- Liver Unit Hospital Universitari Vall d'Hebron and CIBEREHD del Instituto Carlos III Barcelona Spain
- Elena Vargas‐Accarino
- Liver Unit Hospital Universitari Vall d'Hebron and CIBEREHD del Instituto Carlos III Barcelona Spain
- Hiroshi Abe
- Division of Gastroenterology and Hepatology Shinmatsudo Central General Hospital Chiba Japan
- Hirokazu Takahashi
- Liver Center Saga University Hospital Saga Japan
- Kaori Inoue
- Liver Center Saga University Hospital Saga Japan
- Jee‐Fu Huang
- Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan
- Wan‐Long Chuang
- Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan
- Ming‐Lun Yeh
- Kaohsiung Medical University Hospital Kaohsiung Taiwan
- Chia‐Yen Dai
- Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan
- Chung‐Feng Huang
- Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan
- Mindie H. Nguyen
- Division of Gastroenterology and Hepatology, Department of Medicine Stanford University Medical Center Palo Alto California USA
- Ming‐Lung Yu
- Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan
- DOI
- https://doi.org/10.1002/kjm2.12771
- Journal volume & issue
-
Vol. 40,
no. 2
pp. 188 – 197
Abstract
Abstract Elevated serum gamma‐glutamyl transferase (GGT) levels are associated with chronic hepatitis B (CHB)‐related hepatocellular carcinoma. However, their role in predicting mortality in patients with CHB treated with nucleotide/nucleoside analogs (NAs) remains elusive. Altogether, 2843 patients with CHB treated with NAs were recruited from a multinational cohort. Serum GGT levels before and 6 months (Month‐6) after initiating NAs were measured to explore their association with all‐cause, liver‐related, and non‐liver‐related mortality. The annual incidence of all‐cause mortality was 0.9/100 person‐years over a follow‐up period of 17,436.3 person‐years. Compared with patients who survived, those who died had a significantly higher pretreatment (89.3 vs. 67.4 U/L, p = 0.002) and Month‐6‐GGT levels (62.1 vs. 38.4 U/L, p 75 percentile of pretreatment GGT levels was observed with respect to the all‐cause mortality (trend p < 0.001). Pretreatment serum GGT levels predicted all‐cause, liver‐related, and non‐liver‐related mortality in patients with CHB treated with NAs.
Keywords
