Communications Biology (Jan 2022)

Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics

  • Kenichiro Ito,
  • Yoshihiko Matsuda,
  • Ayako Mine,
  • Natsuki Shikida,
  • Kazutoshi Takahashi,
  • Kyohei Miyairi,
  • Kazutaka Shimbo,
  • Yoshimi Kikuchi,
  • Atsushi Konishi

DOI
https://doi.org/10.1038/s42003-022-03015-6
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 10

Abstract

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Peptides composed of two or more tandemly linked macrocyclic peptides binding to growth factor/cytokine receptors (STaMPtides) are useful growth factor/cytokine mimetics. The peptides can be produced from bacterial cells and bioactivity is demonstrated (HGF, EPO, TPO).