IL-27 Negatively Regulates Tip-DC Development during Infection

Gongguan Liu; Osama Abas; Yong Fu; Yanli Chen; Ashley B. Strickland; Donglei Sun; Meiqing Shi

doi:10.1128/mBio.03385-20

mBio (Feb 2021)

IL-27 Negatively Regulates Tip-DC Development during Infection

Gongguan Liu,
Osama Abas,
Yong Fu,
Yanli Chen,
Ashley B. Strickland,
Donglei Sun,
Meiqing Shi

Affiliations

Gongguan Liu: Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
Osama Abas: Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
Yong Fu: Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
Yanli Chen: Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
Ashley B. Strickland: Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
Donglei Sun: Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
Meiqing Shi: ORCiD; Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA

DOI: https://doi.org/10.1128/mBio.03385-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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TNF/iNOS-producing dendritic cells (Tip-DCs) are at the front line as immune effector cells to fight off a broad range of invading microbes. Excessive development of Tip-DCs contributes to tissue destruction.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal