Radical Smiles Rearrangement: An Update

Abstract

Over the decades the Smiles rearrangement and its variants have become essential synthetic tools in modern synthetic organic chemistry. In this mini-review we summarized some very recent results of the radical version of these rearrangements. The selected examples illustrate the synthetic power of this approach, especially if it is incorporated into a domino process, for the preparation of polyfunctionalized complex molecules.

Keywords

• radical chemistry
• Smiles rearrangement
• domino reactions
• radical cascade
• heterocycle