Nature Communications (Feb 2020)
Clonal competition within complex evolutionary hierarchies shapes AML over time
- Carl Sandén,
- Henrik Lilljebjörn,
- Christina Orsmark Pietras,
- Rasmus Henningsson,
- Karim H. Saba,
- Niklas Landberg,
- Hanna Thorsson,
- Sofia von Palffy,
- Pablo Peña-Martinez,
- Carl Högberg,
- Marianne Rissler,
- David Gisselsson,
- Vladimir Lazarevic,
- Gunnar Juliusson,
- Helena Ågerstam,
- Thoas Fioretos
Affiliations
- Carl Sandén
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Henrik Lilljebjörn
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Christina Orsmark Pietras
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Rasmus Henningsson
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Karim H. Saba
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Niklas Landberg
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Hanna Thorsson
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Sofia von Palffy
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Pablo Peña-Martinez
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Carl Högberg
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Marianne Rissler
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- David Gisselsson
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Vladimir Lazarevic
- Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital
- Gunnar Juliusson
- Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital
- Helena Ågerstam
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- Thoas Fioretos
- Division of Clinical Genetics, Department of Laboratory Medicine, Lund University
- DOI
- https://doi.org/10.1038/s41467-019-14106-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
Clonal evolution and heterogeneity has strong implications for treatment response in acute myeloid leukemia. Here, the authors use patient derived in vivo modelling to highlight the complex clonal and evolutionary dynamics underpinning acute myeloid leukemia progression.
