Antihyperlipidemic potential of oil extracted from Ilisha africana on rats

Abstract

This work aimed at evaluating the antihypolipidaemic potential of oil extracted from Ilisha Africana on rats. The oil was extracted using a soxlhet device and underwent chemical analysis prior to in vivo assays. Twenty four female Wistar adult rats were randomly divided into four groups of 6 rats each. During a three-week experiment, group 1 was fed with standard laboratory diet (SLD); group 2 received SLD supplemented with cooked egg yolk (5 g/day/rat);group 3 was fed with SLD supplemented with I. Africana oil (1 g/day/kg of body mass) andgroup 4 was fed with SLD supplemented with cooked egg yolk and I. Africana oil. Liver, lung, kidney, adipose tissues and heart were later removed, weighted and analyzed. Some bloodbiochemical parameters were also measured. Results showed that I. Africanaoil is of good quality. Hyperlipidemic diet significantly (p ˂ 0.05) increased cholesterolemia, triglyceridemia, glycemia and proteinemia in group 2 compared to other groups. Supplementation with the fish oil significantly (p ˂ 0.05) decreased total-cholesterol, LDL-cholesterol, triglyceride, glycemia, proteinemia and increased levels of HDL-cholesterolin group 3 compared to group 2 and 4. I. Africana oil reduced cholesterolemia, triglyceridemia, glycemia and proteinemia in group 4 compared to group 2. This study shows thatI. Africana oil can be used in prevention of hyperlipidemia.

Keywords

• Ilisha africana
• Wistar rats
• Obesity
• Antihyperlipidemia