Nature Communications (Oct 2019)

Oligomeric state of the ZIKV E protein defines protective immune responses

  • Stefan W. Metz,
  • Ashlie Thomas,
  • Alex Brackbill,
  • John Forsberg,
  • Michael J. Miley,
  • Cesar A. Lopez,
  • Helen M. Lazear,
  • Shaomin Tian,
  • Aravinda M. de Silva

DOI
https://doi.org/10.1038/s41467-019-12677-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 7

Abstract

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Many human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that recognize similar epitopes as human antibodies from Zika infected people.