An efficient approach to endow TiNbTaZr implant with osteogenic differentiation and antibacterial activity in vitro

Yingjing Fang; Qingge Wang; Zhi Yang; Wenyue Yang; Liqiang Wang; Jiayin Ma; Yuanfei Fu

Materials & Design (Sep 2022)

An efficient approach to endow TiNbTaZr implant with osteogenic differentiation and antibacterial activity in vitro

Yingjing Fang,
Qingge Wang,
Zhi Yang,
Wenyue Yang,
Liqiang Wang,
Jiayin Ma,
Yuanfei Fu

Affiliations

Yingjing Fang: Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
Qingge Wang: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China
Zhi Yang: Department of Prosthodontics, Shanghai Xuhui District Dental Center, 500 Fenglin Road, Shanghai 200032, China
Wenyue Yang: Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
Liqiang Wang: State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; National Facility for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China; Corresponding authors.
Jiayin Ma: Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China; Corresponding authors.
Yuanfei Fu: Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China; Department of Dental Technology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China; Corresponding authors.

Journal volume & issue: Vol. 221
p. 110987

Abstract

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Osteogenic differentiation and antibacterial property are two-core requirements for bone implants, but typically they are not compatible. Zinc (Zn) as a common bioactive material is widely used in the medical field. A balance between antibacterial and osteogenic activity can be achieved at appropriate Zn concentration. In this study, the TNTZ/Zn micro/nano-composites were prepared by doping Zn nanoparticles onto Ti-35Nb-2Ta-3Zr (TNTZ) surface through the friction stir processing (FSP) technique. The results of material characterization revealed the homogeneous distribution of Zn, the presence of α″ martensite, and the increase in microhardness in the stir zone. Due to the solid metallurgical bonding between Zn NPs and substrate, Zn ions were released slowly and may be biologically responsive through body fluid corrosion. In terms of biological activity, the expression of adhesion-related protein vinculin and osteogenic differentiation genes were up-regulated by TNTZ/Zn, which improved the early adhesion and osteogenic differentiation of bone marrow stromal stem cells. Besides, TNTZ/Zn presented excellent antibacterial properties, and direct contact with the fine grain surface containing Zn NPs may be the dominant mechanism. TNTZ/Zn micro/nano-composites have excellent mechanical properties, osteogenic differentiation and antibacterial properties, providing an efficient strategy for titanium alloy surface modification and showing tremendous potential in dental applications.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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