GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage

Lauren A. Callender; Johannes Schroth; Elizabeth C. Carroll; Conor Garrod-Ketchley; Lisa E. L. Romano; Eleanor Hendy; Audrey Kelly; Paul Lavender; Arne N. Akbar; J. Paul Chapple; Sian M. Henson

doi:10.1038/s41467-021-23715-7

Nature Communications (Jun 2021)

GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage

Lauren A. Callender,
Johannes Schroth,
Elizabeth C. Carroll,
Conor Garrod-Ketchley,
Lisa E. L. Romano,
Eleanor Hendy,
Audrey Kelly,
Paul Lavender,
Arne N. Akbar,
J. Paul Chapple,
Sian M. Henson

Affiliations

Lauren A. Callender: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Johannes Schroth: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Elizabeth C. Carroll: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Conor Garrod-Ketchley: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Lisa E. L. Romano: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Eleanor Hendy: Peter Gorer Department of Immunobiology and Asthma UK Centre in Allergic Mechanisms of Asthma, King’s College London
Audrey Kelly: Peter Gorer Department of Immunobiology and Asthma UK Centre in Allergic Mechanisms of Asthma, King’s College London
Paul Lavender: Peter Gorer Department of Immunobiology and Asthma UK Centre in Allergic Mechanisms of Asthma, King’s College London
Arne N. Akbar: Division of Infection and Immunity, Department of Immunology, University College London
J. Paul Chapple: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Sian M. Henson: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London

DOI: https://doi.org/10.1038/s41467-021-23715-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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