Lupus Science and Medicine (Apr 2021)
Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network
- Richard A Furie,
- Andrew Filer,
- Michael H Weisman,
- Judith A James,
- Kenneth Kalunian,
- Chaim Putterman,
- H Michael Belmont,
- Ilfita Sahbudin,
- Karim Raza,
- Maria Dall'Era,
- Jill P Buyon,
- Diane L Kamen,
- Karen Salomon-Escoto,
- Kazuyoshi Ishigaki,
- Patrick Dunn,
- Betty Diamond,
- David Wofsy,
- Michele Bombardieri,
- Vivian Bykerk,
- Ming Wu,
- Soumya Raychaudhuri,
- Hemant Suryawanshi,
- Thomas Tuschl,
- Christopher Ritchlin,
- Maureen McMahon,
- Jennifer Grossman,
- Philip M Carlucci,
- Alessandra Nerviani,
- Peter M Izmirly,
- Fan Zhang,
- Felice Rivellese,
- Joan Bathon,
- Zhu Zhu,
- Qian Xiao,
- Jessica Li,
- Holden Maecker,
- Nir Hacohen,
- Jennifer Anolik,
- Javier Rangel-Moreno,
- Nida Meednu,
- Susan Goodman,
- Lindsy Forbess,
- Mariko Ishimori,
- Kevin Deane,
- David Hildeman,
- Yuhong Li,
- Robert Clancy,
- ANNE DAVIDSON,
- Matthias Kretzler,
- Larry Moreland,
- Harris Perlman,
- Peter Gregersen,
- Celine C Berthier,
- Andrea Fava,
- David Boyle,
- Derek M Fine,
- Ami Ben-Artzi,
- P J Utz,
- Melanie Smith,
- Beatrice Goilav,
- Carla Cuda,
- Andrew McDavid,
- Joshua Keegan,
- Ilya Korsunsky,
- Joel Guthridge,
- Kevin Wei,
- Arnon Arazi,
- Thomas Eisenhaure,
- Michael Brenner,
- Susan Macwana,
- Pavel Morozov,
- Manjunath Kustagi,
- Gerald Watts,
- Kristina K Deonaraine,
- Jose Monroy-Trujillo,
- Mohamed G Atta,
- Kristin Haag,
- William Apruzzese,
- Sean Connery,
- Fernanda Payan-Schober,
- Kerry Cho,
- Jennifer Goff,
- Aparna Nathan,
- Joseph Mears,
- Nghia Millard,
- Kathryn Weinand,
- Saori Sakaue,
- Bill Robinson,
- Wade DeJager,
- Louis Bridges,
- Laura Donlin,
- Edward DiCarlo,
- Amit Lakhanpal,
- Heather Sherman,
- Anvita Singaraju,
- Lorien Shakib,
- Brendan Boyce,
- Darren Tabechian,
- Jen Albrecht,
- James Lederer,
- A Helena Jonsson,
- Daimon Simmons,
- Gregory Keras,
- Adam Chicoine,
- Zhihan Jian Li,
- Mandy McGeachy,
- Gary Firestein,
- Arnold Ceponis,
- Diane Horowitz,
- Salina Dominguez,
- Arthur Mandelin,
- Anjali Thakrar,
- Mike Holers,
- Jennifer Seifert,
- Constanino Pitzalis,
- Ellen Gravallese,
- Jennifer Barnas,
- Raymond Hsu,
- Steven Woodle,
- Paul Hoover,
- Michael Peters,
- Tony Jones,
- David Lieb,
- Jeffrey Hodgin,
- Raji Menon
Affiliations
- Richard A Furie
- Division of Rheumatology, Northwell Health, Great Neck, New York, USA
- Andrew Filer
- 2Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Glasgow, Birmingham, Newcastle., Glasgow, United Kingdom
- Michael H Weisman
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA
- Judith A James
- Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
- Kenneth Kalunian
- 9University of California, San Diego, La Jolla, United States of America
- Chaim Putterman
- Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
- H Michael Belmont
- 2 Rheumatology, NYU Grossman School of Medicine, New York City, New York, USA
- Ilfita Sahbudin
- Institute of Inflammation and Ageing, University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom
- Karim Raza
- 3NIHR Birmingham Biomedical Research Centre, Birmingham, United Kingdom
- Maria Dall'Era
- University of California San Francisco, San Francisco, California, USA
- Jill P Buyon
- Department of Medicine, NYU Grossman School of Medicine, New York City, New York, USA
- Diane L Kamen
- Medical University of South Carolina, Charleston, South Carolina, USA
- Karen Salomon-Escoto
- Kazuyoshi Ishigaki
- Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- Patrick Dunn
- Betty Diamond
- 8The Feinstein Institute for Medical Research, Manhasset, United States of America
- David Wofsy
- 7UCSF Medical Center, San Francisco, United States of America
- Michele Bombardieri
- Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, UK
- Vivian Bykerk
- Hospital for Special Surgery, New York, NY, United States of America
- Ming Wu
- 1 Department of Thoracic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine,Zhejiang University, Hangzhou, Zhejiang Province, People`s Republic of China
- Soumya Raychaudhuri
- Hemant Suryawanshi
- Thomas Tuschl
- Christopher Ritchlin
- Maureen McMahon
- Medicine - Rheumatology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA
- Jennifer Grossman
- 13University of California, Los Angeles CA, United States of America
- Philip M Carlucci
- Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA
- Alessandra Nerviani
- 1William Harvey Research Institute, Queen Mary University of London, UK, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
- Peter M Izmirly
- Department of Medicine, NYU Grossman School of Medicine, New York City, New York, USA
- Fan Zhang
- Department of Pathophysiology, Guizhou Medical University, Guiyang, China
- Felice Rivellese
- Queen Mary University of London – William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
- Joan Bathon
- 2 Columbia University Medical Center, New York, New York, USA
- Zhu Zhu
- 1 Department of Neurology, University of California Irvine, Irvine, California, USA
- Qian Xiao
- 1 Mental Health Center, Xiangya Hospital, Central South University, Changsha, Hunan, China
- Jessica Li
- Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA
- Holden Maecker
- Nir Hacohen
- 3Harvard Medical School, Boston, United States of America
- Jennifer Anolik
- Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA
- Javier Rangel-Moreno
- 1University of Rochester School of Medicine, Division of Allergy, Immunology and Rheumatology, Rochester, United States of America
- Nida Meednu
- 1University of Rochester School of Medicine, Division of Allergy, Immunology and Rheumatology, Rochester, United States of America
- Susan Goodman
- 2Hospital for Special Surgery, Weill Cornell Medicine, Rheumatology, New York, United States of America
- Lindsy Forbess
- Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA
- Mariko Ishimori
- Department of Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA
- Kevin Deane
- 5 The Open University, Milton Keynes, UK
- David Hildeman
- 10University of Cincinnati, Cincinnati, United States of America
- Yuhong Li
- Robert Clancy
- Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York City, New York, USA
- ANNE DAVIDSON
- 8The Feinstein Institute for Medical Research, Manhasset, United States of America
- Matthias Kretzler
- 9University of Michigan, Ann Arbor, United States of America
- Larry Moreland
- Orthopedics, University of Colorado, Denver, Colorado, USA
- Harris Perlman
- Northwestern University, Medicine/Rheumatology, Chicago, United States of America
- Peter Gregersen
- Celine C Berthier
- Internal Medicine, Department of Nephrology, University of Michigan, Ann Arbor, MI, USA
- Andrea Fava
- 1Johns Hopkins University, Baltimore, United States of America
- David Boyle
- Derek M Fine
- Division of Nephrology, Johns Hopkins University, Baltimore, MD, USA
- Ami Ben-Artzi
- P J Utz
- Melanie Smith
- clinical psychologist
- Beatrice Goilav
- Carla Cuda
- Northwestern University, Medicine/Rheumatology, Chicago, United States of America
- Andrew McDavid
- Joshua Keegan
- Ilya Korsunsky
- Joel Guthridge
- 1Oklahoma Medical Research Foundation, Arthritis and Clinical Immunology, Oklahoma City, United States of America
- Kevin Wei
- Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
- Arnon Arazi
- 4Broad Institute, Cambridge, United States of America
- Thomas Eisenhaure
- Michael Brenner
- Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States of America
- Susan Macwana
- Pavel Morozov
- Manjunath Kustagi
- Gerald Watts
- Kristina K Deonaraine
- Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA
- Jose Monroy-Trujillo
- 11Nephrology, Johns Hopkins University, USA
- Mohamed G Atta
- 11Nephrology, Johns Hopkins University, USA
- Kristin Haag
- Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA
- William Apruzzese
- 9Division of Rheumatology, Immunology, Allergy, Department of Medicine, Brigham and Women’s Hospital, Boston, USA
- Sean Connery
- Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA
- Fernanda Payan-Schober
- Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA
- Kerry Cho
- Nephrology Division, University of California San Francisco, San Francisco, CA, USA
- Jennifer Goff
- Author
- Aparna Nathan
- Joseph Mears
- Nghia Millard
- Kathryn Weinand
- Saori Sakaue
- Bill Robinson
- Wade DeJager
- Louis Bridges
- Laura Donlin
- Weill Cornell Medical College, Department of Medicine, New York, NY, United States of America
- Edward DiCarlo
- Amit Lakhanpal
- Department of Medicine, Division of Rheumatology, Hospital for Special Surgery, New York, New York, USA
- Heather Sherman
- Anvita Singaraju
- Lorien Shakib
- Brendan Boyce
- 8 Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
- Darren Tabechian
- Jen Albrecht
- James Lederer
- A Helena Jonsson
- Daimon Simmons
- Gregory Keras
- Adam Chicoine
- Zhihan Jian Li
- Mandy McGeachy
- Gary Firestein
- Arnold Ceponis
- Diane Horowitz
- Salina Dominguez
- Northwestern University, Medicine/Rheumatology, Chicago, United States of America
- Arthur Mandelin
- Northwestern University, Medicine/Rheumatology, Chicago, United States of America
- Anjali Thakrar
- Mike Holers
- Jennifer Seifert
- CU Anschutz Medical Campus, Aurora, United States of America
- Constanino Pitzalis
- Ellen Gravallese
- Jennifer Barnas
- Raymond Hsu
- Steven Woodle
- Paul Hoover
- Michael Peters
- Tony Jones
- David Lieb
- Jeffrey Hodgin
- 3Pathology, University of Michigan, USA
- Raji Menon
- DOI
- https://doi.org/10.1136/lupus-2021-000522
- Journal volume & issue
-
Vol. 8,
no. 1
Abstract
Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required.
