Nature Communications (Oct 2018)
SMYD2 glutathionylation contributes to degradation of sarcomeric proteins
Abstract
Ischemic reperfusion or nutrient deprivation that produces reactive oxygen species can lead to a loss of muscle contractile function. Here the authors show that glutathionylation of the lysine methyltransferase SMYD2 contributes to degradation or disassembly of sarcomeres.