Drug Design, Development and Therapy (May 2021)
Consolidation Treatment and Long-Term Prognosis of Rituximab in Minimal Change Disease and Focal Segmental Glomerular Sclerosis
Abstract
Li Lin,1 Weiming Wang,1 YiFan Wu,2 JingYuan Xie,1 Xiao Li,1 XiaoXia Pan,1 Wen Zhang,1 Jing Xu,1 YiKai Cai,1 Hong Ren,1 Nan Chen1 1Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China; 2Biomedical and Health Informatics, University of Washington, Seattle, WA, USACorrespondence: Hong Ren; Nan ChenDepartment of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, No. 197, Ruijin Er Road, Shanghai, People’s Republic of ChinaTel +86 21 64370045, extension 665233Fax +86 21 64456419Email [email protected]; [email protected]: There is currently a lack of studies investigating long-term prognosis and the necessity of further rituximab (RTX) consolidation treatment for minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). The aim of this study was to evaluate the efficacy of RTX for these diseases and to investigate whether a consolidation treatment can lower risks of relapse and reinforce long-term remission.Patients and Methods: A retrospective study was conducted. The relapse and remission of 70 patients treated with 1 course of RTX treatment (4 infusions of 375 mg/m2) over a median follow-up time of 27 months (12– 60 months) were analyzed. The rates of patients that were able to achieve non-relapse for a duration of 24 months between RTX consolidation therapy and non-consolidation therapy were compared.Results: There were 67 cases (95.71%) of remission and 3 cases (4.29%) of non-remission. The average number of relapses decreased from 3.7± 2.5 times before the treatment to 0.8± 1.8 times after treatment (P < 0.001). The average avannual number of relapses decreased from 1.3± 1.2 times/year to 0.2± 0.3 times/year (P < 0.001). The results from the Cox proportional-hazards model showed that the risk of relapse in patients who received RTX non-consolidation treatment was significantly higher than those with consolidation treatment (odds ratios (OR) 20.9, 95% confidence intervals (CI) OR 5.7– 75.7, p< 0.001). The 24-month relapse-free rate was also significantly higher in patients with consolidation therapy compared with non-consolidation therapy (86.36% vs 25%, p< 0.001). No adverse events were recorded.Conclusion: RTX is highly effective in treating MCD and FSGS, and RTX consolidation therapy may be recommended to reinforce long-term remissions.Keywords: RTX, MCD, FSGS, consolidation, therapeutic effect
