Acta Crystallographica Section E (Jan 2009)

1,2,3,4-Tetrahydro-1,4-methanonaphthalene-2,3-diol

  • Jian Xu,
  • Hao Xu,
  • Ji-cai Quan,
  • Fei Sha,
  • Cheng Yao

DOI
https://doi.org/10.1107/s1600536808041068
Journal volume & issue
Vol. 65, no. 1
pp. o79 – o79

Abstract

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The title compound, C11H12O2, is an intermediate in the synthesis of Varenicline, a nicotinic receptor partial agonist used to treat smoking addiction. In the crystal structure, there is an intramolecular O—H...O hydrogen bond that generates an S(5) ring motif. Intermolecular O—H...O hydrogen bonds form centrosymmetric dimers and also link these dimers into chains along the a axis.