Metronidazole Modified-Release Therapy Using Two Different Polymeric Systems Gels or Films: Clinical Study for the Treatment of Periodontitis
Mônica Danielle Ribeiro Bastos,
Tatiane Cristina Dotta,
Beatriz Roque Kubata,
Cássio do Nascimento,
Ana Paula Macedo,
Fellipe Augusto Tocchini de Figueiredo,
Millena Mangueira Rocha,
Maria Paula Garofo Peixoto,
Maíra Peres Ferreira,
Osvaldo de Freitas,
Vinicius Pedrazzi
Affiliations
Mônica Danielle Ribeiro Bastos
Department of Dental Materials and Prosthodontics Ribeirão Preto, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo 14040-904, Brazil
Tatiane Cristina Dotta
Department of Dental Materials and Prosthodontics Ribeirão Preto, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo 14040-904, Brazil
Beatriz Roque Kubata
Department of Dental Materials and Prosthodontics Ribeirão Preto, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo 14040-904, Brazil
Cássio do Nascimento
Department of Dental Materials and Prosthodontics Ribeirão Preto, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo 14040-904, Brazil
Ana Paula Macedo
Department of Dental Materials and Prosthodontics Ribeirão Preto, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo 14040-904, Brazil
Fellipe Augusto Tocchini de Figueiredo
Department of Dental Materials and Prosthodontics Ribeirão Preto, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo 14040-904, Brazil
Millena Mangueira Rocha
Department of Dental Materials and Prosthodontics Ribeirão Preto, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo 14040-904, Brazil
Maria Paula Garofo Peixoto
Department of Pharmaceutical Sciences, Ribeirão Preto School of Pharmaceutical Sciences, University of São Paulo, São Paulo 14040-900, Brazil
Maíra Peres Ferreira
Department of Pharmaceutical Sciences, Ribeirão Preto School of Pharmaceutical Sciences, University of São Paulo, São Paulo 14040-900, Brazil
Osvaldo de Freitas
Department of Pharmaceutical Sciences, Ribeirão Preto School of Pharmaceutical Sciences, University of São Paulo, São Paulo 14040-900, Brazil
Vinicius Pedrazzi
Department of Dental Materials and Prosthodontics Ribeirão Preto, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo 14040-904, Brazil
This study evaluated the efficacy of semisolid systems (gels) and films containing a combination of metronidazole (MTZ) and metronidazole benzoate after scaling and root-planing (SRP) for periodontitis. In total, 45 patients with stage I or II periodontitis were enrolled and divided into 3 groups: 1—SRP—control; 2—SRP + Film with MTZ; 3—SRP + Gel with MTZ. The pH of gingival crevicular fluid (GCF) before/after treatments, MTZ concentrations, and drug release using high-performance liquid chromatography were investigated. The effects were evaluated by longitudinal monitoring of clinical parameters (probing depth—PD, clinical attachment level—CAL, and bleeding on probing—BP). MTZ and MTZ-benzoate concentrations in the periodontal pocket and pH showed no statistical difference after application. SRP + Gel presented the lowest CAL values. For SRP + Film and SRP + Gel, higher PD values were observed at T0 compared to all groups. A relevant reduction in BP was observed in SRP + Film and SRP + Gel groups at all times compared to T0. Both therapies improved periodontal health compared to SRP alone, reducing PD and BP, and increasing CAL for the gel group, suggesting they are promising for periodontal disease treatment.
