Cancer Management and Research (Mar 2022)
Could Moesin Be a New Marker for Indicating Progression in Endometrial Cancer?
Abstract
Elif Agacayak,1 Aysenur Keles,2 Ugur Deger,3 Mehmet Sirin Ozcelik,1 Nurullah Peker,1 Reyhan Gunduz,1 Murat Akkus,4 Huseyin Buyukbayram2 1Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakır, Turkey; 2Department of Pathology, Dicle University School of Medicine, Diyarbakır, Turkey; 3Department of Obstetrics and Gynecology, Memorial Hospital, Diyarbakır, Turkey; 4Department of Histology and Embryology, Dicle University School of Medicine, Diyarbakır, TurkeyCorrespondence: Elif Agacayak, Dicle University School of Medicine, Department of Gynecology and Obstetrics, Diyarbakir, 21280, Turkey, Tel +90 412 2488001/4904, Fax +90412 2488523, Email [email protected]: This study aims to determine an important parameter in progression from pre-invasive lesions of endometrium to endometrial cancer and also evaluate the effect of this parameter on the progression of endometrial cancer.Material and Method: In our study,30 patients with normal endometrial tissue (group 1), 56 patients who had endometrial hyperplasia without atypia (group 2), 36 patients who had endometrial hyperplasia with atypia (group 3), and 63 patients with endometrial cancer (group 4) were included. Age, parity, body-mass index, systemic diseases, and tumor markers of patients were evaluated. Expression levels of Ezrin, Radixin, and Moesin proteins were immunohistochemically evaluated in terms of frequency, intensity, and score value.Results: When we compared hyperplasia cases with or without atypia; frequency, and score value of ezrin expression and frequency, intensity, and score value of moesin expression was significantly higher in patients who had hyperplasia with atypia (p:0.000 p:0.001 p:0.003, p:0.032 p: 0.035 p:0.015 p:0.005, respectively). It was observed that the frequency and score value of moesin expression were significantly higher in patients with endometrial cancer when compared with patients who had hyperplasia with atypia (p:0.003 p:0.045). The frequency of moesin expression was significantly higher in patients who had postoperative mortality (p:0.030 p:0.039).Conclusion: Increased frequency of moesin expression in the preoperative period in patients with atypical hyperplasia should alert the surgeon in terms of malignancy. If the frequency of moesin expression increases in cases with endometrial cancer, the patient should be followed closely in terms of progression in the postoperative period.Keywords: hyperplasia, endometrial cancer, moesin, progression
