Thiophene anchored two new sets of carbohydrazide for the chemosensing and biological investigation

Abstract

The presence of hazardous metal ions or anions in industrial and domestic water may adversely affect the living systems there. Hence their detection is reducing the risk to human and environmental systems. In this study, we investigate the spectroscopical variations of different analytes and the biological performance of two derivatives of carbohydrazide scaffolds. So, we developed two chemosensors 3TCH and BTTCH to detect Cu2+ and F− in an aqueous medium by using photoluminescence spectroscopy (PL). The BTTCH has also sensitively detected the AcO−. Spectral maxima deviations and colour changes in the concentration in concern can serve as indicators of the interaction that was produced. The limit of detection (LOD) was calculated for all the complexes, which all are in lower limits of quantification and the complex 3TCH + F− showed a much lower value of 8.23 × 10−8 M. The binding constants are calculated using the Benesi-Hildebrand equation, 3TCH + F− showed the highest value (K = 9.39 × 10−7M−1) of the association constant, indicating the highest affinity. Additionally, it was investigated whether the chemosensors could be used with common household items like mouthwash and vinegar.

Keywords

• Chemoselectivity
• Chelation Enhanced Fluorescence Effect
• Metal ion recognition
• Carbohydrazide
• Extended conjugation
• Intramolecular Charge Transfer