Open Medicine
(Apr 2025)
Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
Zhang Fengxia,
Tang Xianhu,
Zeng Zhimei,
Cao Chunyu,
Yun Caocui,
Shen Yue,
Nie Chaohong,
Xiong Ying,
Chulian Mao,
Wu Yueheng,
Xu Ruiquan
Affiliations
Zhang Fengxia
Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Tang Xianhu
Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Zeng Zhimei
Department of Stomatology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Cao Chunyu
Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Yun Caocui
Department of Nephrology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
Shen Yue
Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Nie Chaohong
Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Xiong Ying
Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Chulian Mao
Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Wu Yueheng
Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
Xu Ruiquan
Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, Jiangxi, China
DOI
https://doi.org/10.1515/med-2025-1146
Journal volume & issue
Vol. 20,
no. 1
Abstract
Read online
Diabetic kidney disease (DKD) represents serious diabetes-associated complications, and podocyte loss is an important histologic sign of DKD. The cellular and molecular profiles of podocytes in DKD have yet to be fully elucidated.
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