Nature Communications (Sep 2018)

Asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process

  • Wei Song,
  • Jin-Hui Wang,
  • Jing Wu,
  • Jia Liu,
  • Xiu-Lai Chen,
  • Li-Ming Liu

DOI
https://doi.org/10.1038/s41467-018-06241-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Alpha-functionalized organic acids are building blocks of many bioactive compounds. Here, the authors developed a toolbox-like, modular set of enzymes that reset chiral groups, turning achiral glycine and simple aldehydes into stereodefined α-keto acids, α-hydroxy acids, and α-amino acids.