Comparative Study of Wound Healing Activity of Topical and Oral Ocimum Sanctum Linn in Albino Rats

Abstract

Introduction: Ocimum sanctum, when given orally in one of the studies showed wound healing property. Since majority of the agents tried for wound healing are topical, the present study was planned to compare the oral and topical Ocimum sanctum for wound healing property. Methods: Excision and incision resutured wound models in albino rats were used to study complete epithelisation time, wound contraction, histopathological study and tensile strength of the wounds. Results: The animals were divided into four groups of oral test, control and topical test, control with 6 animals in each group. The time taken for 50% wound contraction and complete eipthelisation by oral Ocimum sanctum, topical Ocimum sanctum was significantly (p<0.001) less compared to oral and topical controls. Histopathological studies showed early inflammatory changes, dense collagen and neovascularisation in wounds treated with oral and topical Ocimum sanctum, compared to respective controls. Mean tensile strength of oral and topical Ocimum sanctum treated wound was significantly great (p<0.001) compared to controls. Interpretation and Conclusion: Oral and topical Ocimum sanctum promoted better granulation tissue, early and complete epithelisation and better tensile strength compared to both controls.

Keywords

• Ocimum sanctum
• Wound healing activity
• topical
• oral